FANDOM


Zig3
A zigzag is a series of alternating bulges or asymmetric internal loops. Solving zigzags requires the use of specific sequences.

Zigzags may be viewed as a "collapsed" symmetric internal loop.

Solving the 1-nt Bulge ZigzagEdit

See also: Brourd's Zigzag Catalog

The 1-nt bulge zigzag has several solutions, each requiring at least 2 GC pairs. In each case, the zigzag can be thought of as an especially unstable 2-2 loop that has collapsed on itself. For a list of zigzag sequences, follow the above link.

Solving the 2-1 Loop ZigzagEdit

21zig
The 2-1 loop zigzag has a large number of solutions and requires at least 1 GC pair to solve.

This loop can be considered an unstable 4-4 loop that has collapsed on itself. To solve the 2-1 loop zigzag, it is necessary to avoid boosting the 4-4 loop that would form by breaking the isolated base pair. The GA/G mismatch and GC/A mismatch both selectively stabilize the 2-1 loop.

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.